The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-PAX8 antibody (ab13611)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Paired box 8
Paired box gene 8
paired box homeotic gene 8
Paired box protein Pax 8
Paired box protein Pax-8
Paired domain gene 8
功能Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
组织特异性Expressed in the excretory system, thyroid gland and Wilms tumors.
疾病相关Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
序列相似性Contains 1 paired domain.
发展阶段In developing excretory system, during thyroid differentiation and in adult thyroid.