Anti-Human Papillomavirus 16 (E7)抗体[SPM405] (ab19938)

概述

  • 产品名称Anti-Human Papillomavirus 16 (E7)抗体[SPM405]
    参阅全部 Human Papillomavirus 16 (E7) 一抗
  • 描述
    小鼠单克隆抗体[SPM405] to人Papillomavirus 16 (E7)
  • 经测试应用适用于: Flow Cyt, ICC/IFmore details
  • 种属反应性
    与反应: Human Papillomavirus (HPV)
  • 免疫原

    Recombinant full length protein (HPV type 16).

  • 阳性对照
    • Cervical tissue infected with HPV16.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 10% PBS, BSA, pH 7.4
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号SPM405
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab19938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.

靶标

  • 相关性E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription
  • 细胞定位Nuclear
  • 数据库链接
    • 别名
      • E7 antibody
      • HPV16 E7 antibody
      • Protein E7 antibody
      • Transforming protein antibody

    Anti-Human Papillomavirus 16 (E7) antibody [SPM405] (ab19938)参考文献

    ab19938 has not yet been referenced specifically in any publications.

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    The conc of this product is 200 ug/ml. The product can be further diluted 1/50 or 1/100 for sue in ICC/IF and Flow Cytometry. Please note the dilutions has to be optimized by the end user. Try lowest dilution fir...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"