Anti-Human Papillomavirus 16 (E7)抗体[716-281] (ab82601)

概述

  • 产品名称Anti-Human Papillomavirus 16 (E7)抗体[716-281]
    参阅全部 Human Papillomavirus 16 (E7) 一抗
  • 描述
    小鼠单克隆抗体[716-281] to人Papillomavirus 16 (E7)
  • 特异性ab82601 recognizes HPV oncoprotein E7, types 16 and 18 (both monomer and dimer forms by Western blot).
  • 经测试应用适用于: WB, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human Papillomavirus (HPV)
  • 免疫原

    HPV oncoprotein E7, type 16.

性能

应用

Our Abpromise guarantee covers the use of ab82601 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent dilution.

靶标

  • 相关性E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription
  • 细胞定位Nuclear
  • 数据库链接
    • 别名
      • E7 antibody
      • HPV16 E7 antibody
      • Protein E7 antibody
      • Transforming protein antibody

    Anti-Human Papillomavirus 16 (E7) antibody [716-281] (ab82601)参考文献

    ab82601 has not yet been referenced specifically in any publications.

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