概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-KEKQDWSSCPDIF
    • 氨基酸407 to 420

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技术指标

Our Abpromise guarantee covers the use of ab23121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-OSBP1 antibody (ab5915)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • OSBP
    • OSBP 1
    • OSBP1_HUMAN
    • Oxysterol binding protein 1
    • Oxysterol-binding protein 1
    see all
  • 功能Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the OSBP family.
    Contains 1 PH domain.
  • 结构域The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
    The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
  • 细胞定位Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
  • Information by UniProt

Human OSBP1 peptide (ab23121)参考文献

ab23121 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"