概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列ENAASAQKATAE
    • 氨基酸241 to 252

技术指标

Our Abpromise guarantee covers the use of ab45438 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

常规信息

  • 别名
    • ORC 6
    • Orc6
    • ORC6_HUMAN
    • ORC6L
    • Origin recognition complex subunit 6
    • origin recognition complex subunit 6 homolog like
    • origin recognition complex subunit 6 homolog like (yeast)
    • origin recognition complex subunit 6 like (yeast)
    see all
  • 功能Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • 疾病相关Defects in ORC6 are the cause of Meier-Gorlin syndrome type 3 (MGORS3) [MIM:613803]. MGORS3 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • 序列相似性Belongs to the ORC6 family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt

Human ORC6L peptide 图像

Human ORC6L peptide (ab45438)参考文献

ab45438 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45438.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"