The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-NUP50 antibody (ab4005)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
50 kDa nucleoporin
Nuclear pore associated protein 60L
Nuclear pore complex protein Nup50
Nuclear pore-associated protein 60 kDa-like
功能Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.
组织特异性Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
序列相似性Contains 1 RanBD1 domain.
结构域Contains FG repeats.
细胞定位Nucleus > nuclear pore complex. Nucleus membrane. Localizes to the nucleoplasmic fibrils of the nuclear pore complex.