概述

  • 产品名称人NUMBL肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列SRSAAASGGPRRPE-C
    • 氨基酸2 to 15

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23104 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-NUMBL antibody (ab5641)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • CAG 3A
    • CAG3A
    • CTG 3a
    • CTG3a
    • NBL
    • NUMB Drosophilia Homolog Like
    • Numb homolog (Drosophila) like
    • Numb homolog like
    • Numb like protein
    • NUMB R
    • Numb-like protein
    • Numb-R
    • Numb-related gene
    • Numb-related protein
    • NUMBL
    • NUMBL_HUMAN
    • NUMBLIKE
    • NUMBR
    • TNRC 23
    • TNRC23
    • Trinucleotide repeat-containing gene 23
    see all
  • 功能Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • 序列相似性Contains 1 PID domain.
  • 结构域The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • 细胞定位Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
  • Information by UniProt

Human NUMBL peptide (ab23104)参考文献

ab23104 has not yet been referenced specifically in any publications.

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