The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-NUMBL antibody (ab5641)
Concentration information loading...
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
NUMB Drosophilia Homolog Like
Numb homolog (Drosophila) like
Numb homolog like
Numb like protein
Trinucleotide repeat-containing gene 23
功能Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
序列相似性Contains 1 PID domain.
结构域The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
细胞定位Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.