概述

描述

  • 性质Synthetic
  • 来源CHO cells

相关产品

技术指标

Our Abpromise guarantee covers the use of ab14141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性ab14141 is the immunising peptide for Numb antibody ab14140 and can be used for blocking studies.
  • 应用

    Blocking - Blocking peptide for Anti-NUMB antibody (ab14140)

  • 形式Liquid
  • 补充说明ab14141 is the immunising peptide for Numb antibody ab14140 and can be used for blocking studies.

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • c14_5527
    • C14orf41
    • FLJ31314
    • h Numb
    • h-Numb
    • Numb
    • Numb homolog
    • Numb homolog (Drosophila)
    • Numb protein homolog
    • NUMB_HUMAN
    • Protein numb homolog
    • Protein S171
    • S171
    see all
  • 功能Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
  • 序列相似性Contains 1 PID domain.
  • 翻译后修饰Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • 细胞定位Membrane.
  • Information by UniProt

Human NUMB peptide (ab14141)参考文献

ab14141 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab14141.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"