概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab39823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    Blocking - Blocking peptide for Anti-Noxa antibody (ab36833)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • Adult T cell leukemia derived PMA responsive
    • APR
    • APR_HUMAN
    • ATL-derived
    • Immediate early response protein APR
    • Immediate-early-response protein APR
    • NOXA
    • Phorbol 12 myristate 13 acetate induced protein 1
    • Phorbol-12-myristate-13-acetate-induced protein 1
    • PMA induced protein 1
    • PMA-induced protein 1
    • PMA-responsive gene
    • Pmaip1
    • Protein Noxa
    see all
  • 功能
    Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
  • 组织特异性
    Highly expressed in adult T-cell leukemia cell line.
  • 序列相似性
    Belongs to the PMAIP1 family.
  • 结构域
    The BH3 motif is essential for pro-apoptotic activity.
  • 细胞定位
    Mitochondrion.
  • Information by UniProt

文献

ab39823 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab39823.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册