概述

描述

  • 性质Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab17100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • atonal
    • basic helix loop helix transcription factor
    • BETA 2
    • Beta cell E box transactivator 2
    • BETA2
    • BHF 1
    • BHF1
    • bHLHa3
    • class A basic helix loop helix protein 3
    • Class A basic helix-loop-helix protein 3
    • MODY 6
    • MODY6
    • NDF1_HUMAN
    • NeuroD
    • NeuroD1
    • Neurogenic differentiation 1
    • Neurogenic differentiation factor 1
    • neurogenic helix loop helix protein NEUROD
    • Neuronal differentiation 1
    see all
  • 功能Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • 疾病相关Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 翻译后修饰Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Human NeuroD1 peptide (ab17100)参考文献

ab17100 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab17100.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"