人Natriuretic肽Receptor B肽(ab42264)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列QNRLLIRAREDFGVE
    • 氨基酸288 to 302

相关产品

技术指标

Our Abpromise guarantee covers the use of ab42264 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Natriuretic Peptide Receptor B antibody (ab14357)

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% Acetic acid

  • 复溶Resuspend in 0.1% acetic acid for required concentration.

常规信息

  • 别名
    • AMDM
    • ANP-B
    • ANPB
    • ANPR-B
    • ANPRB
    • ANPRB_HUMAN
    • Atrial natriuretic peptide B type receptor
    • Atrial natriuretic peptide receptor 2
    • Atrial natriuretic peptide receptor type B
    • Atrionatriuretic peptide receptor B
    • GC-B
    • GCB
    • Guanylate cyclase B
    • GUC 2B
    • GUC2B
    • GUCY2B
    • Natriuretic peptide receptor B
    • Natriuretic peptide receptor B/guanylate cyclase B
    • NPR-B
    • Npr2
    • NPRB
    • NPRBi
    see all
  • 功能Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
  • 疾病相关Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth.
  • 序列相似性Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    Contains 1 guanylate cyclase domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylation of the protein kinase-like domain is required for full activation by CNP.
  • 细胞定位Membrane.
  • Information by UniProt

Human Natriuretic Peptide Receptor B peptide (ab42264)参考文献

ab42264 has not yet been referenced specifically in any publications.

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