概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

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技术指标

Our Abpromise guarantee covers the use of ab39800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-NALP2 antibody (ab36850)

    Western blot

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • CLR19.9
    • FLJ20510
    • Leucine rich repeat and PYD containing protein 2
    • LRR and PYD domains-containing protein 2
    • NACHT
    • NACHT domain
    • NACHT leucine rich repeat and PYD containing 2
    • NACHT LRR and PYD domains containing protein 2
    • NALP2
    • NALP2_HUMAN
    • NBS1
    • NLR family pyrin domain containing 2
    • NLRP2
    • Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2
    • Nucleotide-binding site protein 1
    • PAN1
    • PYPAF2
    • PYRIN containing APAF1 like protein2
    • PYRIN domain and NACHT domain-containing protein 1
    • PYRIN-containing APAF1-like protein 2
    see all
  • 功能Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • 组织特异性Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.
  • 序列相似性Belongs to the NLRP family.
    Contains 1 DAPIN domain.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 结构域The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Human NALP2 peptide (ab39800)参考文献

ab39800 has not yet been referenced specifically in any publications.

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