人N WASP (phospho Y256)肽(ab42793)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

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技术指标

Our Abpromise guarantee covers the use of ab42793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Human WASP sequence has a two amino acid difference in the region surrounding Tyrosine 291.
  • 应用

    Blocking - Blocking peptide for Anti-N WASP (phospho Y256) antibody (ab23395)

    ELISA

  • 形式Liquid
  • 补充说明


    Phosphorylation at serine and tyrosine residues regulates the activity of both proteins. WASP is tyrosine phosphorylated at tyrosine 291 after antigen receptor activation in B-cells and collagen stimulation of platelets. Phosphorylation of the analogous site in N WASP (Tyr-256) stimulates its activity, reduces nuclear N WASP, and is required for neurite extension.

    Human WASP sequence has a two amino acid difference in the region surrounding Tyrosine 291.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

常规信息

  • 别名
    • DKFZp779G0847
    • MGC48327
    • N-WASP
    • Neural Wiskott Aldrich syndrome protein
    • Neural Wiskott-Aldrich syndrome protein
    • NWASP
    • Wasl
    • WASL_HUMAN
    • WASPB
    • Wiskott Aldrich syndrome gene like
    • Wiskott Aldrich syndrome gene like protein
    • Wiskott Aldrich syndrome like
    • WiskottAldrich syndrome like
    see all
  • 功能Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
  • 序列相似性Contains 1 CRIB domain.
    Contains 1 WH1 domain.
    Contains 2 WH2 domains.
  • 细胞定位Cytoplasm > cytoskeleton. Nucleus. Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.
  • Information by UniProt

Human N WASP (phospho Y256) peptide (ab42793)参考文献

ab42793 has not yet been referenced specifically in any publications.

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