概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      DYKSSLIQDGNPM-C
    • 氨基酸
      2 to 14

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-MURF1 antibody (ab4125)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • E3 ubiquitin-protein ligase TRIM63
    • FLJ32380
    • IRF
    • Iris RING finger protein
    • MURF 1
    • MURF-1
    • MuRF1
    • MURF2
    • Muscle specific ring finger protein 1
    • Muscle specific ring finger protein 2
    • Muscle-specific RING finger protein 1
    • OTTHUMP00000008701
    • RING finger protein 28
    • RNF 28
    • RNF28
    • SMRZ
    • Striated muscle RING zinc finger protein
    • TRI63_HUMAN
    • TRIM 63
    • Trim63
    • Tripartite motif containing 63
    • tripartite motif containing 63, E3 ubiquitin protein ligase
    • Tripartite motif containing protein 63
    • Tripartite motif-containing protein 63
    • Ubiquitin ligase TRIM63
    see all
  • 功能
    E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
  • 组织特异性
    Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 1 B box-type zinc finger.
    Contains 1 COS domain.
    Contains 1 RING-type zinc finger.
  • 发展阶段
    Expressed throughout all developmental stages.
  • 结构域
    The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.
  • 细胞定位
    Cytoplasm. Nucleus. Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.
  • Information by UniProt

Human MURF1 peptide (ab22986)参考文献

ab22986 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab22986.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册