概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列DYKSSLIQDGNPM-C
    • 氨基酸2 to 14

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-MURF1 antibody (ab4125)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • E3 ubiquitin-protein ligase TRIM63
    • FLJ32380
    • IRF
    • Iris RING finger protein
    • MURF 1
    • MURF-1
    • MuRF1
    • MURF2
    • Muscle specific ring finger protein 1
    • Muscle specific ring finger protein 2
    • Muscle-specific RING finger protein 1
    • OTTHUMP00000008701
    • RING finger protein 28
    • RNF 28
    • RNF28
    • SMRZ
    • Striated muscle RING zinc finger protein
    • TRI63_HUMAN
    • TRIM 63
    • Trim63
    • Tripartite motif containing 63
    • tripartite motif containing 63, E3 ubiquitin protein ligase
    • Tripartite motif containing protein 63
    • Tripartite motif-containing protein 63
    • Ubiquitin ligase TRIM63
    see all
  • 功能E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
  • 组织特异性Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 B box-type zinc finger.
    Contains 1 COS domain.
    Contains 1 RING-type zinc finger.
  • 发展阶段Expressed throughout all developmental stages.
  • 结构域The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.
  • 细胞定位Cytoplasm. Nucleus. Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.
  • Information by UniProt

Human MURF1 peptide (ab22986)参考文献

ab22986 has not yet been referenced specifically in any publications.

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