概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab39809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    Blocking - Blocking peptide for Anti-MCL1 antibody (ab25956)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • Bcl 2 related protein EAT/mcl1
    • Bcl-2-like protein 3
    • Bcl-2-related protein EAT/mcl1
    • BCL2 related
    • Bcl2-L-3
    • BCL2L3
    • EAT
    • Induced myeloid leukemia cell differentiation protein Mcl 1
    • Induced myeloid leukemia cell differentiation protein Mcl-1
    • MCL 1
    • MCL1
    • MCL1-ES
    • mcl1/EAT
    • MCL1_HUMAN
    • MCL1L
    • MCL1S
    • MGC104264
    • MGC1839
    • Myeloid Cell Leukemia 1
    • Myeloid cell leukemia ES
    • Myeloid cell leukemia sequence 1
    • Myeloid cell leukemia sequence 1 BCL2 related
    • Myeloid cell leukemia sequence 1 isoform 1
    • OTTHUMP00000032794
    • OTTHUMP00000032795
    • TM
    see all
  • 功能Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
  • 序列相似性Belongs to the Bcl-2 family.
  • 翻译后修饰Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
    Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
    Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.
  • 细胞定位Membrane. Cytoplasm. Mitochondrion. Nucleus > nucleoplasm. Cytoplasmic, associated with mitochondria.
  • Information by UniProt

Human MCL1 peptide (ab39809)参考文献

ab39809 has not yet been referenced specifically in any publications.

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