概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列AMDSSLQARLFPG-C
    • 氨基酸2 to 14

技术指标

Our Abpromise guarantee covers the use of ab23137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 4930402F02Rik
    • CT139
    • ESTM5
    • KIF 2C
    • kif2c
    • KIF2C_HUMAN
    • Kinesein Family Member 2C
    • Kinesin family member 2C
    • Kinesin like 6
    • kinesin like 6 (mitotic centromere associated kinesin)
    • Kinesin like protein 6
    • Kinesin like protein KIF2C
    • Kinesin-like protein 6
    • Kinesin-like protein KIF2C
    • KNS L6
    • KNSL 6
    • KNSL6
    • MCAK
    • MGC11883
    • Mitotic centromere associated kinesin
    • Mitotic centromere-associated kinesin
    • OTTHUMP00000010066
    • X83316
    see all
  • 功能Promotes ATP-dependent removal of tubulin dimers from microtubules. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
  • 组织特异性Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
  • 序列相似性Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.
    Contains 1 kinesin-motor domain.
  • 发展阶段Isoform 2 is expressed in fetal testis.
  • 结构域The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by STK12, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
  • 细胞定位Cytoplasm > cytoskeleton. Nucleus. Chromosome > centromere. Chromosome > centromere > kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Centromeric localization requires the presence of BUB1 and SGOL2.
  • Information by UniProt

Human MCAK peptide (ab23137)参考文献

ab23137 has not yet been referenced specifically in any publications.

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