概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列VLPTCPMAEFALPR
    • 氨基酸28 to 41

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技术指标

Our Abpromise guarantee covers the use of ab23302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-MAML1 antibody (ab17019)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Mam-1
    • Mam1
    • MAML 1
    • Maml1
    • MAML1_HUMAN
    • Mastermind like 1
    • Mastermind-like protein 1
    see all
  • 功能Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
  • 组织特异性Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
  • 序列相似性Belongs to the mastermind family.
  • 结构域The C-terminal region is required for transcriptional activation.
  • 细胞定位Nucleus speckle. Nuclear, in a punctate manner.
  • Information by UniProt

Human MAML1 peptide (ab23302)参考文献

ab23302 has not yet been referenced specifically in any publications.

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