概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      VLPTCPMAEFALPR
    • 氨基酸
      28 to 41

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-MAML1 antibody (ab17019)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Mam-1
    • Mam1
    • MAML 1
    • Maml1
    • MAML1_HUMAN
    • Mastermind like 1
    • Mastermind-like protein 1
    see all
  • 功能
    Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
  • 组织特异性
    Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
  • 序列相似性
    Belongs to the mastermind family.
  • 结构域
    The C-terminal region is required for transcriptional activation.
  • 细胞定位
    Nucleus speckle. Nuclear, in a punctate manner.
  • Information by UniProt

Human MAML1 peptide (ab23302)参考文献

ab23302 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23302.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册