概述

  • 产品名称人Mad2L2肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列TLTRQDLNFGQV (amino acids 1-14) of human Mad2L2.
    • 氨基酸3 to 14

技术指标

Our Abpromise guarantee covers the use of ab11254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性This product can be used as the blocking peptide for ab3630.
  • 形式Liquid
  • 补充说明This product can be used as the blocking peptide for ab3630.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: PBS

常规信息

  • 别名
    • Homolog of REV7 S cerevisiae
    • hREV7
    • MAD2 (mitotic arrest deficient yeast, homolog) like 2
    • MAD2 homolog
    • MAD2 like 2
    • MAD2 mitotic arrest deficient like 2
    • MAD2-like protein 2
    • MAD2B
    • Mad2l2
    • MD2L2_HUMAN
    • Mitotic Arrest Deficient 2 L2
    • Mitotic arrest deficient 2-like protein 2
    • Mitotic arrest deficient homolog like 2
    • Mitotic arrest deficient like 2 (yeast)
    • Mitotic arrest deficient yeast homolog
    • Mitotic spindle assembly checkpoint protein MAD2B
    • Polymerase (DNA directed) zeta 2 accessory subunit
    • POLZ2
    • REV 7
    • REV7
    • REV7 homolog
    • Weakly similar to Mitotic MAD2 protein (S cerevisiae)
    see all
  • 功能Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
  • 组织特异性Ubiquitously expressed.
  • 序列相似性Contains 1 HORMA domain.
  • 细胞定位Nucleus. Cytoplasm > cytoskeleton > spindle. Cytoplasm.
  • Information by UniProt

Human Mad2L2 peptide (ab11254)参考文献

ab11254 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab11254.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"