概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-TQDDIEKHQSDAG
    • 氨基酸829 to 841

相关产品

技术指标

Our Abpromise guarantee covers the use of ab50450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Leptin Receptor antibody (ab50424)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • CD 295
    • CD295
    • CD295 antigen
    • Db
    • Fa
    • HuB219
    • LEP R
    • LEP-R
    • LEPR
    • LEPR_HUMAN
    • LEPRD
    • Leptin receptor
    • Leptin receptor fatty
    • Leptin receptor gene related protein
    • Leptin receptor precursor
    • OB R gene related protein
    • OB receptor
    • OB-R
    • OB-RGRP
    • obl
    • Obr
    see all
  • 功能Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.
  • 组织特异性Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 4 fibronectin type-III domains.
    Contains 1 Ig-like (immunoglobulin-like) domain.
  • 结构域The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 翻译后修饰On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt

Human Leptin Receptor peptide (ab50450)参考文献

ab50450 has not yet been referenced specifically in any publications.

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