概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • AccessionQ9H5I1
    • 种属Human
    • 序列CKCGAVTCRGYLN
    • 氨基酸398 to 410

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技术指标

Our Abpromise guarantee covers the use of ab23082 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-KMT1B / SUV39H2 antibody (ab5264)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • FLJ23414
    • H3 K9 HMTase 2
    • H3-K9-HMTase 2
    • Histone H3 K9 methyltransferase 2
    • Histone H3-K9 methyltransferase 2
    • Histone lysine N methyltransferase H3 lysine 9 specific 2
    • Histone lysine N methyltransferase SUV39H2
    • Histone-lysine N-methyltransferase SUV39H2
    • KMT1B
    • Lysine N methyltransferase 1B
    • Lysine N-methyltransferase 1B
    • sSuppressor of variegation 3 9 homolog 2 (Drosophila)
    • Su(var)3 9 Drosophila homolog of 2
    • Su(var)3 9 homolog 2
    • Su(var)3-9 homolog 2
    • Suppressor of variegation 3 9 homolog 2
    • Suppressor of variegation 3-9 homolog 2
    • Suv39h2
    • SUV92_HUMAN
    see all
  • 功能Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
  • 序列相似性Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.
    Contains 1 chromo domain.
    Contains 1 post-SET domain.
    Contains 1 pre-SET domain.
    Contains 1 SET domain.
  • 结构域Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin.
  • 细胞定位Nucleus. Chromosome > centromere. Associates with centromeric constitutive heterochromatin.
  • Information by UniProt

Human KMT1B / SUV39H2 peptide (ab23082)参考文献

ab23082 has not yet been referenced specifically in any publications.

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