概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-QAKLFPLHQETAAS
    • 氨基酸1019 to 1032

技术指标

Our Abpromise guarantee covers the use of ab23133 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • D12S1889
    • KIF 5A
    • Kif5a
    • KIF5A_HUMAN
    • Kinesin family member 5A
    • Kinesin heavy chain isoform 5A
    • Kinesin Heavy Chain Neuron Specific
    • Kinesin heavy chain neuron-specific 1
    • MY050
    • Neuronal kinesin heavy chain
    • NKHC
    • NKHC 1
    • SPG 10
    see all
  • 功能Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).
  • 组织特异性Distributed throughout the CNS but is highly enriched in subsets of neurons.
  • 疾病相关Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10 (SPG10) [MIM:604187]. An inherited degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
  • 序列相似性Belongs to the kinesin-like protein family. Kinesin subfamily.
    Contains 1 kinesin-motor domain.
  • 结构域Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
  • 细胞定位Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton. Concentrated in the cell body of the neurons, particularly in the perinuclear region.
  • Information by UniProt

Human Kinesin 5A peptide (ab23133)参考文献

ab23133 has not yet been referenced specifically in any publications.

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