The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-KHSRP antibody (ab83291)
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Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Far upstream element-binding protein 2
FUSE binding protein 2
FUSE-binding protein 2
KH type splicing regulatory protein
KH type splicing regulatory protein (FUSE binding protein 2)
KH type-splicing regulatory protein
功能Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
组织特异性Detected in neural and non-neural cell lines.
序列相似性Belongs to the KHSRP family. Contains 4 KH domains.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
细胞定位Nucleus. Cytoplasm. A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.