概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列WEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGG
    • 氨基酸648 to 697

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技术指标

Our Abpromise guarantee covers the use of ab111652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-KHSRP antibody (ab83291)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • Far upstream element-binding protein 2
    • FBP2
    • FUBP2
    • FUBP2_HUMAN
    • FUSE binding protein 2
    • FUSE-binding protein 2
    • KH type splicing regulatory protein
    • KH type splicing regulatory protein (FUSE binding protein 2)
    • KH type-splicing regulatory protein
    • KHSRP
    • KSRP
    • p75
    see all
  • 功能Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
  • 组织特异性Detected in neural and non-neural cell lines.
  • 序列相似性Belongs to the KHSRP family.
    Contains 4 KH domains.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Cytoplasm. A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.
  • Information by UniProt

Human KHSRP peptide (ab111652)参考文献

ab111652 has not yet been referenced specifically in any publications.

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