The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-KDM2B antibody (ab5199)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
[Histone-H3]-lysine-36 demethylase 1B
CXXC-type zinc finger protein 2
F box and leucine rich repeat protein 10
F box protein FBL10
F-box and leucine-rich repeat protein 10
F-box protein FBL10
F-box/LRR-repeat protein 10
JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein
JmjC domain-containing histone demethylation protein 1B
Jumonji C domain containing histone demethylase 1B
Jumonji domain-containing EMSY-interactor methyltransferase motif protein
Lysine (K) specific demethylase 2B
Lysine-specific demethylase 2B
Protein containing CXXC domain 2
Protein-containing CXXC domain 2
功能Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.