概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab64574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-JMJD6 antibody (ab64575)

  • 纯度70 - 90% by HPLC.

  • 形式Liquid
  • 补充说明

    Blocking peptide for ab64575

     

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • Apoptotic cell clearance receptor
    • Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    • Histone arginine demethylase JMJD6
    • JmjC domain-containing protein 6
    • JMJD 6
    • JMJD6
    • JMJD6_HUMAN
    • Jumonji domain containing 6
    • Jumonji domain-containing protein 6
    • KIAA0585
    • Lysyl-hydroxylase JMJD6
    • Peptide-lysine 5-dioxygenase JMJD6
    • Phosphatidylserine receptor
    • Protein PTDSR
    • PSR
    • PTDSR
    • PTDSR 1
    • PTDSR1
    see all
  • 功能Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
  • 组织特异性Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.
  • 序列相似性Belongs to the JMJD6 family.
    Contains 1 JmjC domain.
  • 结构域The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
  • 细胞定位Nucleus > nucleoplasm. Nucleus > nucleolus. Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
  • Information by UniProt

Human JMJD6 peptide (ab64574)参考文献

ab64574 has not yet been referenced specifically in any publications.

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