The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-ITK antibody (ab9707)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Homolog of mouse T cell itk/tsk
IL 2 inducible T cell kinase
IL2 inducible T cell kinase
Interleukin 2 inducible T cell kinase
T cell specific kinase
Tyrosine protein kinase
Tyrosine protein kinase ITK/TSK
Tyrosine protein kinase Lyk
Tyrosine-protein kinase ITK/TSK
Tyrosine-protein kinase Lyk
功能Plays a role in T-cell proliferation and differentiation.
组织特异性T-cell lines and natural killer cell lines.
疾病相关Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1) [MIM:613011]. LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.
序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Contains 1 Btk-type zinc finger. Contains 1 PH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.
细胞定位Cell membrane. Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells.