概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-QRSFFRENQQITV
    • 氨基酸414 to 426

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-IRF8 antibody (ab3428)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • H ICSBP
    • H-ICSBP
    • HGNC:5358
    • HICSBP
    • ICSBP
    • ICSBP 1
    • ICSBP1
    • Interferon consensus sequence binding protein
    • Interferon consensus sequence binding protein 1
    • Interferon consensus sequence-binding protein
    • Interferon regulatory factor 8
    • IRF 8
    • IRF-8
    • Irf8
    • IRF8_HUMAN
    • MYLS
    see all
  • 功能Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.
  • 组织特异性Predominantly in lymphoid tissues.
  • 序列相似性Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 翻译后修饰Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.
  • 细胞定位Nucleus.
  • Information by UniProt

Human IRF8 peptide (ab22947)参考文献

ab22947 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"