功能Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
组织特异性Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
序列相似性Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
翻译后修饰In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. TRAF6-mediated ubiquitination is required for IRF7 activation.
细胞定位Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.