概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab24662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • IMD39
    • Interferon regulatory factor 7
    • Interferon regulatory factor 7H
    • IRF 7
    • IRF 7A
    • IRF 7H
    • IRF-7
    • IRF7
    • IRF7_HUMAN
    • IRF7A
    • IRF7B
    • IRF7C
    • IRF7H
    see all
  • 功能Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.
  • 组织特异性Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
  • 序列相似性Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 翻译后修饰In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.
    TRAF6-mediated ubiquitination is required for IRF7 activation.
  • 细胞定位Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
  • Information by UniProt

Human IRF7 peptide (ab24662)参考文献

ab24662 has not yet been referenced specifically in any publications.

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