概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列KTSDITQARVKSC
    • 氨基酸337 to 349

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22943 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-IRF2 antibody (ab3388)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • DKFZp686F0244
    • Interferon regulatory factor 2
    • IRF 2
    • IRF-2
    • IRF2
    • IRF2_HUMAN
    see all
  • 功能Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
  • 组织特异性Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
  • 序列相似性Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 翻译后修饰Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
    The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
  • 细胞定位Nucleus.
  • Information by UniProt

Human IRF2 peptide (ab22943)参考文献

ab22943 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"