人Integrin beta 4 (phospho Y1526)肽(ab42719)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 修饰phospho Y1526

技术指标

Our Abpromise guarantee covers the use of ab42719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性This peptide is found in all three Integrin beta 4 isoforms and is highly conserved in rat and mouse Integrin beta 4.
  • 应用

    Blocking - Blocking peptide for Anti-Integrin beta 4 (phospho Y1526) antibody (ab29044)

    ELISA

  • 形式Liquid
  • 补充说明The concentration of this peptide is specified on the datasheet.This peptide is found in all three Integrin beta 4 isoforms and is highly conserved in rat and mouse Integrin beta 4.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

常规信息

  • 别名
    • CD 104
    • CD104
    • CD104 antigen
    • gp150
    • Integrin beta 4 subunit
    • Integrin beta-4
    • ITB4_HUMAN
    • ITG B4
    • ITGB 4
    • Itgb4
    see all
  • 功能Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
  • 组织特异性Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
  • 疾病相关Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
    Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
  • 序列相似性Belongs to the integrin beta chain family.
    Contains 1 Calx-beta domain.
    Contains 4 fibronectin type-III domains.
    Contains 1 PSI domain.
    Contains 1 VWFA domain.
  • 结构域The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
  • 细胞定位Membrane.
  • Information by UniProt

Human Integrin beta 4 (phospho Y1526) peptide (ab42719)参考文献

ab42719 has not yet been referenced specifically in any publications.

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