The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-ING2 antibody (ab2643)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
ING 1 like tumor suppressor protein
ING1 like tumor suppressor protein
Inhibitor of growth 1 like
Inhibitor of growth 1 like protein
Inhibitor of growth 1-like protein
Inhibitor of growth family member 1 like
Inhibitor of growth family member 2
Inhibitor of growth protein 2
功能Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
组织特异性Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
序列相似性Belongs to the ING family. Contains 1 PHD-type zinc finger.
结构域The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
细胞定位Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.