概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-DKSTEKTKKDRRSR
    • 氨基酸267 to 280

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技术指标

Our Abpromise guarantee covers the use of ab22925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-ING2 antibody (ab2643)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • ING 1 like tumor suppressor protein
    • ING 1L
    • ING 2
    • ING1 like tumor suppressor protein
    • ING1L
    • ING1Lp
    • ING2
    • ING2_HUMAN
    • Inhibitor of growth 1 like
    • Inhibitor of growth 1 like protein
    • Inhibitor of growth 1-like protein
    • Inhibitor of growth family member 1 like
    • Inhibitor of growth family member 2
    • Inhibitor of growth protein 2
    • p32
    • p33 ING2
    • p33ING2
    see all
  • 功能Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
  • 组织特异性Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
  • 序列相似性Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • 结构域The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
  • 细胞定位Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
  • Information by UniProt

Human ING2 peptide (ab22925)参考文献

ab22925 has not yet been referenced specifically in any publications.

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