Anti-Human IgM抗体[MH15-1] (ab34029)

概述

  • 产品名称Anti-Human IgM抗体[MH15-1]
    参阅全部 Human IgM 一抗
  • 描述
    小鼠单克隆抗体[MH15-1] to人IgM
  • 特异性The monoclonal is highly specific for the IgM isotype.
  • 经测试应用适用于: IHC-P, IHC-Fr, ICCmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Isolated IgM (Human).

  • 阳性对照
    • Tonsil.

性能

应用

Our Abpromise guarantee covers the use of ab34029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
IHC-Fr
ICC
  • 应用说明ICC: 1/5 - 1/10.
    IHC-Fr: 1/5 - 1/10.
    IHC-P: 1/5 - 1/10 (based on the Indirect Method). With a normal ABC Method the dilution can be 5-10 times higher, but the optimal dilution should be tested by serial dilution. Perform protease digestion trypsin pretreatment. Dilute immediately before use with PBS or TRIS.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.
    • 细胞定位Cell Membrane and Secreted
    • 数据库链接
    • 别名
      • Immunoglobin heavy chain constant region mu edit item name - Immunoglobin heavy chain mu constant region antibody
      • Immunoglobin heavy chain constant region mu antibody
      • AGM1 antibody
      • Constant region of heavy chain of IgM antibody
      • DKFZp686I15196 antibody
      • DKFZp686I15212 antibody
      • FLJ00385 antibody
      • Ig mu chain C region antibody
      • IGHM antibody
      • IgM heavy chain constant region antibody
      • Immunoglobin heavy constant mu antibody
      • Immunoglobulin mu antibody
      • MGC104996 antibody
      • MGC52291 antibody
      • MU antibody
      • VH antibody
      see all

    Anti-Human IgM antibody [MH15-1] (ab34029)参考文献

    ab34029 has not yet been referenced specifically in any publications.

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