Anti-Human Ig light chain抗体[MRC OX-12] (ab111891)

概述

  • 产品名称Anti-Human Ig light chain抗体[MRC OX-12]
    参阅全部 Human Ig light chain 一抗
  • 描述
    小鼠单克隆抗体[MRC OX-12] to人Ig light chain
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Pooled rat serum IgG

  • 阳性对照
    • Rat strain Lewis, Wistar, Brown Norway, Buffalo and Fischer 344 spleen cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.02% Sodium azide
    Constituent: 99.98% PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab11891 was purified from ascitic fluid via Protein G Chromatography
  • 克隆单克隆
  • 克隆编号MRC OX-12
  • 骨髓瘤P3-NS1/1-Ag4-1
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab111891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.06µg for 106 cells.

ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 相关性There are only two types of light chain: kappa and lambda in mammals. Other types of light chains are found in lower vertebrates as the Ig-Light-Iota chain in Chondrichthyes and Teleostei. In each antibody, only one type is present and the two chains are identical. Each light chain has two successive domains: one constant and one variable domain. In humans 60% of light chains are kappa and 40% lambda,whereas in the mouse 95% of light chains are kappa. The amino acid sequences of lambda chains vary slightly at a few positions, allowing them to be classified into subtypes. The number of subtypes varies between species. Monoclonal immunoglobulin free light chains (FLC) are found in the serum and urine (Bence-Jones protein) of patients with a number of B-cell proliferative disorders, including multiple myeloma. Changes in serum FLC concentrations can provide a rapid and sensitive indication of response to treatment.
  • 细胞定位Cell Membrane: single-pass type I membrane protein and Secreted
  • 数据库链接
  • 别名
    • HCAK1 antibody
    • Ig kappa chain antibody
    • IGKC antibody
    • Immunoglobulin kappa constant antibody
    • immunoglobulin kappa light chain (VJ) antibody
    • kappa 1 immunoglobulin light chain antibody
    • KM antibody
    • MGC111575 antibody
    • MGC62011 antibody
    • MGC72072 antibody
    • MGC88770 antibody
    • MGC88771 antibody
    • MGC88809 antibody
    see all

Anti-Human Ig light chain antibody [MRC OX-12] 图像

  • ab111891 at 0.06 µg/10<> cells detecting Human Ig light chain in Lewis Rat spleen cells by Flow Cytometry. 40% more of the cells were stained than in the control (Mouse IgG2a). Strains Wistar, Brown Norway, Buffalo and Fischer 344 were also positive in this assay.

Anti-Human Ig light chain antibody [MRC OX-12] (ab111891)参考文献

ab111891 has not yet been referenced specifically in any publications.

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