概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列QKVVSHCLEL GAASAHYIAG TMEDMTFAEQ FVAQAGKLMG GLDMLILNHI

相关产品

技术指标

Our Abpromise guarantee covers the use of ab99223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-HSD11B1 antibody (ab83522)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • 11 beta HSD 1
    • 11 beta HSD1
    • 11 beta hydroxysteroid dehydrogenase 1
    • 11 DH
    • 11-beta hydroxysteroid dehydrogenase, type 1
    • 11-beta-HSD1
    • 11-beta-hydroxysteroid dehydrogenase 1
    • 11-DH
    • 11DH
    • Corticosteroid 11 beta dehydrogenase isozyme 1
    • Corticosteroid 11-beta-dehydrogenase isozyme 1
    • CORTRD2
    • DHI1_HUMAN
    • HDL
    • HSD 11
    • HSD11
    • HSD11B
    • HSD11B1
    • HSD11L
    • Hydroxysteroid (11 beta) dehydrogenase
    • Hydroxysteroid (11 beta) dehydrogenase 1
    • MGC13539
    • SDR26C1
    • short chain dehydrogenase/reductase family 26C, member 1
    see all
  • 功能Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  • 组织特异性Widely expressed. Highest expression in liver.
  • 疾病相关Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
  • 序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 翻译后修饰Glycosylated.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt

Human HSD11B1 peptide (ab99223)参考文献

ab99223 has not yet been referenced specifically in any publications.

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