概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-EDPQSKEPAGEA
    • 氨基酸2 to 13

技术指标

Our Abpromise guarantee covers the use of ab50554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • 3' 5' exonuclease ERI 1
    • 3' 5' exonuclease ERI1
    • 3' EXO
    • 3' exoribonuclease
    • 3' HEXO
    • 3' histone mRNA exonuclease 1
    • 3''-5'' exonuclease eri1
    • 3''-5'' exoribonuclease 1
    • 3'EXO
    • 3'HEXO
    • ERI 1
    • Eri 1 homolog
    • Eri-1 homolog
    • eri1
    • Eri1 homolog
    • ERI1_HUMAN
    • HEXO
    • Histone mRNA 3' end specific exonuclease
    • Histone mRNA 3' end specific exoribonuclease
    • Histone mRNA 3''-end-specific exoribonuclease
    • Histone mRNA 3''-exonuclease 1
    • MGC35395
    • Protein 3''hExo
    • THEX 1
    • THEX1
    • Three prime histone mRNA exonuclease 1
    see all
  • 功能RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
  • 序列相似性Contains 1 exonuclease domain.
    Contains 1 SAP domain.
  • 结构域The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3'-end histone mRNA exonuclease activity.
  • 细胞定位Cytoplasm. Nucleus. Nucleus > nucleolus.
  • Information by UniProt

Human HEXO peptide (ab50554)参考文献

ab50554 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab50554.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"