The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-HEC1 antibody (ab3393)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
from Entrez Gene ;
Highly expressed in cancer
Highly expressed in cancer protein
Highly expressed in cancer rich in leucine heptad repeats
Kinetochore associated 2
Kinetochore associated protein 2
Kinetochore protein Hec1
Kinetochore protein NDC80 homolog
Kinetochore-associated protein 2
NDC80 homolog kinetochore complex component
NDC80 kinetochore complex component homolog
NDC80, S. cerevisiae, homolog of
Retinoblastoma associated protein HEC
Retinoblastoma-associated protein HEC
功能Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
序列相似性Belongs to the NDC80/HEC1 family.
发展阶段Expression peaks in mitosis.
翻译后修饰Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
细胞定位Nucleus. Chromosome > centromere > kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.