概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-YEKKATLIKSSEE
    • 氨基酸630 to 642

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技术指标

Our Abpromise guarantee covers the use of ab22944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-HEC1 antibody (ab3393)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • from Entrez Gene ;
    • HEC
    • Highly expressed in cancer
    • Highly expressed in cancer protein
    • Highly expressed in cancer rich in leucine heptad repeats
    • HsHec1
    • hsNDC80
    • Kinetochore associated 2
    • Kinetochore associated protein 2
    • Kinetochore protein Hec1
    • Kinetochore protein NDC80 homolog
    • Kinetochore-associated protein 2
    • KNTC2
    • ndc80
    • NDC80 homolog kinetochore complex component
    • NDC80 kinetochore complex component homolog
    • NDC80, S. cerevisiae, homolog of
    • NDC80_HUMAN
    • Retinoblastoma associated protein HEC
    • Retinoblastoma-associated protein HEC
    • TID3
    see all
  • 功能Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
  • 序列相似性Belongs to the NDC80/HEC1 family.
  • 发展阶段Expression peaks in mitosis.
  • 翻译后修饰Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
  • 细胞定位Nucleus. Chromosome > centromere > kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
  • Information by UniProt

Human HEC1 peptide (ab22944)参考文献

ab22944 has not yet been referenced specifically in any publications.

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