The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-GRB2 antibody (ab2234)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Abundant SRC homology
Adapter protein GRB2
Epidermal growth factor receptor binding protein
Epidermal growth factor receptor binding protein GRB2
GRB2 adapter protein
Growth factor receptor bound protein 2
Growth factor receptor bound protein 3
Growth factor receptor-bound protein 2
SH2/SH3 adapter GRB2
功能Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
序列相似性Belongs to the GRB2/sem-5/DRK family. Contains 1 SH2 domain. Contains 2 SH3 domains.
结构域The SH3 domains mediate interaction with RALGPS1 and SHB.