概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列EHWSYGLRPG
    • 氨基酸24 to 33

相关产品

技术指标

Our Abpromise guarantee covers the use of ab41769 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Neutralising

    Blocking - Blocking peptide for Anti-GnRH antibody (ab5617)

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • GnRH associated peptide 1
    • GNRH1
    • Gonadotrophin releasing hormone 1
    • GRH
    • HH12
    • LHRH
    • LNRH
    • Luliberin I
    • Luteinizing releasing hormone
    • Lutenizing hormome releasing hormone
    • Progonadoliberin 1
    • Progonadoliberin I
    • Prolactin release inhibiting factor
    see all
  • 相关性Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
  • 细胞定位Secreted

Human GnRH peptide (ab41769)参考文献

This product has been referenced in:
  • Higa-Nakamine S  et al. Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons. J Cell Physiol 227:2492-501 (2012). Read more (PubMed: 21898395) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"