人Glucocorticoid Receptor alpha肽(ab39764)

概述

  • 产品名称人Glucocorticoid Receptor alpha肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列CEIITNQIPKYSNGNIKK
    • 氨基酸755 to 771

技术指标

Our Abpromise guarantee covers the use of ab39764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Neutralising

    Blocking - Blocking peptide for Anti-Glucocorticoid Receptor alpha antibody - ChIP Grade (ab3580)

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Double distilled water.

常规信息

  • 别名
    • GCCR
    • GCR
    • Glucocorticoid receptor
    • Glucocorticoid receptor alpha isoform
    • GR
    • GRL
    • NR3C1
    • Nuclear receptor subfamily 3 group C member 1
    see all
  • 相关性Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the Glucocorticoid Receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform translocates from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR alpha has a greater affinity for GR response elements (GREs) than GR beta only when in the ligand bound state.
  • 细胞定位Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand; nuclear after ligand-binding.

Human Glucocorticoid Receptor alpha peptide (ab39764)参考文献

ab39764 has not yet been referenced specifically in any publications.

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