概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列Pyr-GPWLEEEEEAGWMDF
    • 氨基酸77 to 92

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技术指标

Our Abpromise guarantee covers the use of ab42257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Gastrin antibody (ab14182)

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

  • 复溶Resuspend in 60% acetonitrile in 0.01M ammoiumbicarbonate for required concentration (vial content is 0.1 mg).

常规信息

  • 别名
    • Component II
    • G14
    • G17
    • G34
    • G52
    • G6
    • GAS
    • Gast
    • GAST_HUMAN
    • Gastrin
    • Gastrin component I
    • Gastrin component II
    • Gastrin component III
    • Gastrin precursor
    • Gastrin-14
    • Gastrin-17
    • Gastrin-34
    • Gastrin-52
    • Gastrin-6
    • Gastrin-71
    see all
  • 功能Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
  • 序列相似性Belongs to the gastrin/cholecystokinin family.
  • 翻译后修饰Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
  • 细胞定位Secreted.
  • Information by UniProt

Human Gastrin peptide (ab42257)参考文献

ab42257 has not yet been referenced specifically in any publications.

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