人G protein beta subunit like肽(ab39766)

概述

  • 产品名称人G protein beta subunit like肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab39766 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • G protein beta subunit like
    • G protein beta subunit-like
    • Gable
    • GbetaL
    • GBL
    • GBL protein
    • LST8
    • LST8_HUMAN
    • Mammalian lethal with SEC13 protein 8
    • MGC111011
    • mLST8
    • MTOR associated protein LST8 homolog (S. cerevisiae)
    • POP3
    • POP3 homolog (S. pombe)
    • Protein GbetaL
    • Target of rapamycin complex subunit LST8
    • TORC subunit LST8
    • WAT1
    • WAT1 homolog (S. pombe)
    see all
  • 功能Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
  • 组织特异性Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
  • 序列相似性Belongs to the WD repeat LST8 family.
    Contains 7 WD repeats.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Human G protein beta subunit like peptide (ab39766)参考文献

ab39766 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab39766.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"