概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-GVYSRPVLNTS
    • 氨基酸463 to 473

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23074 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-FOXA1 antibody - ChIP Grade (ab5089)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • forkhead box A1
    • Forkhead box protein A1
    • FOX A1
    • FOXA1
    • FOXA1_HUMAN
    • hepatocyte nuclear factor 3 alpha
    • Hepatocyte nuclear factor 3-alpha
    • HNF 3A
    • HNF-3-alpha
    • HNF-3A
    • HNF3A
    • MGC33105
    • TCF 3A
    • TCF-3A
    • TCF3A
    • Transcription factor 3A
    see all
  • 功能Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
  • 组织特异性Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
  • 序列相似性Contains 1 fork-head DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Human FOXA1 peptide (ab23074)参考文献

ab23074 has not yet been referenced specifically in any publications.

Product Wall

I am very sorry to hear you are disappointed after using the FOXA1 peptide (aa 463-473, ab23074) with the Anti-FOXA1 antibody (ab55178).

The antibody is monoclonal antibody that will only bind one epitope in the FOXA1 protein. This antibody w...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"