- 氨基酸948 to 961
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Faciogenital dysplasia 1 protein
- 功能Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
- 组织特异性Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
- 疾病相关Aarskog-Scott syndrome
Defects in FGD1 are found in a patient with non-syndromal X-linked mental retardation.
- 序列相似性Contains 1 DH (DBL-homology) domain.
Contains 1 FYVE-type zinc finger.
Contains 2 PH domains.
- 结构域The DH domain is involved in interaction with CCPG1.
- 细胞定位Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Associated with membrane ruffles and lamellipodia.
Information by UniProt
Human FGD1 peptide (ab45555)参考文献
has not yet been referenced specifically in any publications.
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