概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-QIPRTLEEFVGFH
    • 氨基酸615 to 627

技术指标

Our Abpromise guarantee covers the use of ab22783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • F1A alpha
    • F1A-alpha
    • F1AA
    • Fem-1-like death receptor-binding protein alpha
    • Fem-1-like in apoptotic pathway protein alpha
    • Fem1 homolog b
    • FEM1 like death receptor binding protein
    • FEM1-beta
    • FEM1b
    • FEM1B_HUMAN
    • Protein fem-1 homolog B
    see all
  • 功能Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
  • 组织特异性Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the fem-1 family.
    Contains 8 ANK repeats.
    Contains 1 TPR repeat.
  • 细胞定位Cytoplasm. Nucleus. In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.
  • Information by UniProt

Human FEM 1B peptide (ab22783)参考文献

ab22783 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab22783.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"