概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列EIPNPPTSKCITY
    • 氨基酸2 to 14

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技术指标

Our Abpromise guarantee covers the use of ab22954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-EZH1 antibody (ab3670)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Enhancer of zeste homolog 1
    • Enhancer of zeste homolog 1 (Drosophila)
    • ENX-2
    • ENX2
    • Ezh1
    • EZH1_HUMAN
    • Histone-lysine N-methyltransferase EZH1
    see all
  • 功能Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
  • 序列相似性Belongs to the histone-lysine methyltransferase family. EZ subfamily.
    Contains 1 SET domain.
  • 细胞定位Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.
  • Information by UniProt

Human EZH1 peptide (ab22954)参考文献

ab22954 has not yet been referenced specifically in any publications.

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