人Estrogen Related Receptor alpha肽(ab39777)

概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      MSSQVVGIEPLYIKAE
    • 氨基酸
      1 to 16

技术指标

Our Abpromise guarantee covers the use of ab39777 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Neutralising

    Blocking

  • 纯度
    > 90 % SDS-PAGE.
    This peptide is greater than 70% pure.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Double distilled water or equivalent after reconstitution.

常规信息

  • 别名
    • Err 1
    • ERR a
    • ERR alpha
    • ERR-alpha
    • Err1
    • ERR1 protein
    • ERR1_HUMAN
    • ERRa
    • ERRalpha
    • ESRL 1
    • ESRL1
    • ESRR A
    • Esrra
    • Estrogen receptor like 1
    • Estrogen receptor related 1
    • estrogen receptor related receptor alpha
    • Estrogen receptor-like 1
    • Estrogen related receptor alpha
    • Estrogen-related receptor alpha
    • Estrra
    • hERR1
    • NR3B1
    • Nuclear receptor subfamily 3 group B member 1
    • Steroid hormone receptor ERR1
    see all
  • 功能
    Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.
  • 序列相似性
    Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 翻译后修饰
    Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
    Sumoylated by SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activiy, but has no effect on subcellular location nor on DNA binding.
  • 细胞定位
    Nucleus.
  • Information by UniProt

文献

ab39777 has not yet been referenced specifically in any publications.

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