功能Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.
组织特异性Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.
序列相似性Belongs to the EPS8 family. Contains 1 PH domain. Contains 1 SH3 domain.
结构域The SH3 domain mediates interaction with SHB.
翻译后修饰Phosphorylated by several receptor tyrosine kinases.