The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-ELF5 antibody (ab13581)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
E74 like factor 5
E74 like factor 5 (ets domain transcription factor)
E74-like factor 5
Epithelium restricted ESE 1 related Ets factor
Epithelium restricted ESE1 related Ets factor
Epithelium specific Ets transcription factor 2
Epithelium-restricted ESE-1-related Ets factor
Epithelium-specific Ets transcription factor 2
Ets domain TF
Ets domain transcription factor
ETS related transcription factor Elf 5
ETS related transcription factor Elf5
ETS-related transcription factor Elf-5
功能Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
组织特异性Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.
序列相似性Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.
结构域The PNT domain acts as a transcriptional activator.