概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-LAIKTKNFGFV
    • 氨基酸2789 to 2799

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-EDD antibody (ab4376)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 4432411E13Rik
    • AW549941
    • C77315
    • D030042K14
    • DD5
    • E3 identified by differential display
    • E3 ubiquitin protein ligase, HECT domain containing, 1
    • E3 ubiquitin-protein ligase
    • E3 ubiquitin-protein ligase UBR5
    • EDD
    • EDD 1
    • EDD1
    • FLJ11310
    • HECT domain-containing 1
    • hHYD
    • HYD
    • Hyperplastic discs protein homolog
    • Hyperplastic discs, Drosophila, homolog of
    • KIAA0896
    • MGC57263
    • mKIAA0896
    • Progestin induced protein
    • Progestin-induced protein
    • Rat100
    • Ubiquitin protein ligase
    • Ubiquitin protein ligase E3 component n recognin 5
    • UBR5
    • UBR5_HUMAN
    see all
  • 功能E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.
  • 组织特异性Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    Contains 1 PABC domain.
    Contains 1 UBR-type zinc finger.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt

Human EDD peptide (ab23029)参考文献

ab23029 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"