概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-LHRTETFPAYRSEH
    • 氨基酸293 to 306

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-DOK5 antibody (ab24360)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • chromosome 20 open reading frame 180
    • Docking protein 5
    • DOK 5
    • DOK5
    • DOK5 protein
    • DOK5_HUMAN
    • Downstream of tyrosine kinase 5
    • Insulin receptor substrate 6
    • IRS-6
    • IRS6
    see all
  • 功能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
  • 组织特异性Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
  • 序列相似性Belongs to the DOK family. Type B subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 结构域PTB domain mediates receptor interaction.
  • 翻译后修饰Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Information by UniProt

Human DOK5 peptide (ab45623)参考文献

ab45623 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45623.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"